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Synthesis of the 5-(2-haloethyl)pyrimidines 4-6.
Reagents and conditions: (i) NaOMe, ether, HCOOCH3, 24 h; (ii) urea, 3M HCl, 4 °C, 24 h; (iii) NaOEt, ethanol, reflux, 6 h; (iv) HI, -5 °C, 90 min; (v) POCl3, reflux, 1h; (vi) NaOMe, reflux, 6 h.
