Table 1.
Antimalarial activity of compounds by schizont maturation assay against chloroquine sensitive (CS) and chloroquine resistant (CR) strains of P. falciparum
| Compound | IC50 | IC90 | IC99 | |||
|---|---|---|---|---|---|---|
| CS | CR | CS | CR | CS | CR | |
| 3.1 | 18.44 | 19.87 | 25.64 | 29.87 | 31.45 | 36.36 |
| 3.2 | 17.14 | 21.87 | 24.36 | 31.45 | 32.14 | 36.31 |
| 3.3 | 12.14 | 14.52 | 13.52 | 17.14 | 36.89 | 39.87 |
| 3.4 | 9.41 | 9.21 | 9.12 | 10.52 | 11.42 | 12.36 |
| 3.5 | 8.96 | 9.67 | 11.36 | 14.31 | 12.89 | 15.87 |
| 3.6 | 14.56 | 16.31 | 14.87 | 15.83 | 16.21 | 17.33 |
| 4.1 | 12.11 | 11.21 | 4.11 | 4.52 | 6.11 | 6.88 |
| 4.2 | 9.17 | 8.14 | 7.21 | 8.31 | 7.98 | 8.47 |
| 4.3 | 6.14 | 7.39 | 10.88 | 9.13 | 11.43 | 10.19 |
| 4.4 | 3.87 | 3.53 | 3.42 | 6.21 | 4.54 | 7.41 |
| 4.5 | 3.64 | 3.54 | 19.55 | 21.69 | 31.48 | 39.78 |
| Chloroquine | 0.0241 | 0.038 | ||||