Table 1.

DDI-score-based datasets

Histogram’s bin generation	Normalized	Values	Abbreviation
Fixed number of bins	Yes	5, 10, 15, 30, 50	NBN sets
	No	5, 10, 15, 30, 50	NB sets
Fixed-size bins	Yes	1, 5, 10, 15, 20	SBN sets
	No	1×10−6, 2.5×10−6, 5×10−6	SB sets

Different configurations were used to generate 18 datasets based on the frequency distribution of domain-domain interaction scores. There exist four types of datasets according to (1) whether the histogram’s bins are defined with fixed size or fixed number and (2) whether or not the score frequencies are absolute or normalized values