Fig. 1.

Decreased insulin-like growth factor type1 receptor (IGF-1R) expression correlates with basal-like, triple-negative breast cancer (TNBC). a, b Analysis of IGF-1R expression from the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) dataset. (a) Boxplot representation of IGF-1R expression levels in estrogen receptor (ER+)/progesterone receptor (PR+) breast cancer compared to TNBC (Student’s t test, P < 2.2 × 10^− 16). (b) Boxplot representation of IGF-1R expression levels in the prediction analysis of microarray 50 (PAM50) subtypes: basal-like, luminal A (LumA), or luminal B (LumB) (Student’s t test, basal-like versus LumA P < 2.2 × 10^− 16; basal-like versus LumB P < 2.2 × 10^− 16). c, d Kaplan–Meier survival plot from analysis of the METABRIC dataset of overall survival in patients with low IGF-1R compared to high IGF-1R expression in all breast cancers (c) (log-rank test, P = 0.0021) and only ER+/PR+ breast cancer (d) (log-rank test, P = 0.0018). BC, breast cancer