Fig. 7.

Insulin-like growth factor type1 receptor (IGF-1R) expression is inversely correlated with cytokine and matrix metalloproteinase (MMP) expression in human breast cancer. a-c Analysis of gene expression from the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) dataset in human breast tumors with low (IGF-1R z-score < − 1) versus high (IGF-1R z-score > 1) IGF-1R expression determined by z-score. Representation of IL-6 (a) (Student’s t test; P < 2.2 × 10^− 16), C-C motif chemokine ligand 2 (CCL2) (b) (Student’s t test; P < 2.2 × 10^− 16), and MMP9 (c) (Student’s t test; P < 2.2 × 10^− 16) expression