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. Author manuscript; available in PMC: 2018 Nov 20.
Published in final edited form as: J Med Chem. 2018 Oct 16;61(20):9316–9334. doi: 10.1021/acs.jmedchem.8b01248

Figure 4.

Figure 4.

Displacement of structured waters from BRD4(1). Crystal structure of BRD4(1) with DMSO (left, yellow, PDB ID 4IOR) and compound V (right, yellow, PDB ID 6MH1), with structurally conserved water molecules shown in cyan.