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. Author manuscript; available in PMC: 2018 Nov 20.
Published in final edited form as: J Med Chem. 2018 Oct 16;61(20):9316–9334. doi: 10.1021/acs.jmedchem.8b01248

Figure 5.

Figure 5.

Cellular evaluation of lead compounds confirming target engagement. (A) Cellular thermal-shift assay with compound V indicating thermal stabilization of BRD4 and p38α in A549 cells, with β-actin used as a loading control. (B) Western blots of expressed c-Myc levels in MM.1S cells, with GAPDH used as a loading control.