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. Author manuscript; available in PMC: 2018 Nov 20.
Published in final edited form as: J Med Chem. 2018 Oct 16;61(20):9316–9334. doi: 10.1021/acs.jmedchem.8b01248

Figure 6.

Figure 6.

Inhibition of NF-κB signaling and an NF-κB target gene. (A) NF-κB−luciferase-reporter assay with A549 cells with 20, 5, and 1 μM (+)-JQ1 and 10, 5, and 1 μM IV, V, and RVX-208. (B) Sandwich IL-8 ELISA with 10, 1, and 0.1 μM (+)-JQ1, V, SB-203580, and RVX-208. Data reported are means ± SEM values (n = 3 biological replicates) normalized to compound-induced (I) control values. All samples except the not-induced (NI) control were induced with 10 ng/mL TNFα. ANOVA comparisons to the three RVX-208 treatments; ns, not statistically significant; ***p < 0.001; ****p < 0.0001. See Figure S3 for compound-mediated-cellular-cytotoxicity data.