TABLE I.
Summary of demographics and characteristics in patients with EoE and control subjects
| Demographics/characteristics | Patients with EoE (n = 71)* | Control subjects (n = 210) | P value |
|---|---|---|---|
| Age (y), median (range) | 11.0 (2.0–18.0) | 12.9 (12.0–16.1) | .002‡ |
| Female sex, no. (%) | 23 (32.4) | 99 (47.1) | .03† |
| BMI (kg/m2), mean (SD) | 20.3 (5.6) | 21.0 (4.6) | .30‡ |
| Race/ethnicity | |||
| Asian | 0 | 7 | .20† |
| Black | 3 | 33 | −01† |
| Hispanic | 1 | 9 | .46† |
| White | 63 | 130 | <.001† |
| Other | 4 | 31 | .06† |
| Peak eosinophil count/hpf, median (IQR) | 40 (25–60) | NA | NA |
| Food impaction Sx, no. (%) | 12 (16.9) | NA | NA |
| Dysphagia Sx, no. (%) | 37 (52.1) | NA | NA |
| Vomiting Sx, no. (%) | 22 (31.0) | NA | NA |
| Abdominal pain Sx, no. (%) | 26 (36.6) | NA | NA |
| Reflux Sx, no. (%) | 20 (28.2) | NA | NA |
| Asthma Hx, no. (%) | 22 (31.0) | 55 (26.2) | .43† |
| Rhinitis Hx, no. (%) | 41 (57.7) | 41 (20.5) | <.001† |
| Eczema Hx, no. (%) | 25 (35.2) | 41 (20.2) | .02† |
| Food allergy Hx, no. (%) | 20 (28.2) | 25 (11.9) | .001† |
| Family Hx of EoE/reflux, no. (%) | 14 (19.7) | NA | NA |
| Consumes CM or dairy, no. (%) | 53 (74.6) | 205 (98.1)ǁ | <.001† |
| Hx of acute reactions to CM, no. (%) | 6 (8.5) | 3 (0.4) | .01† |
| Total IgE (IU/mL), GM (95% CI) | 122 (80.4–157) | 68.0 (56.3–82.2) | .01§ |
| CM sIgE, detectable, no. (%)¶ | 54 (76) | 76 (36) | <.001† |
| CM sIgE (IU/mL), GM (95% CI) | 1.17 (0.74–1.85) | 0.28 (0.24–0.33) | <.001§ |
BMI, Body mass index; GM, geometric mean; Hx, history; IQR, interquartile range; Sx, symptoms.
*
Sixty-five of 71 patients with EoE had been treated with a proton pump inhibitor.
†, ‡, and §
P values were calculated by using the χ2 or Fisher exact test, the Student t test, or the Mann-Whitney test, respectively.
ǁ
Of the 210 subjects, 209 answered the questionnaire regarding dairy consumption; 1 or more servings per week of CM or dairy was considered positive.
¶
Defined as 0.1 IU/mL or greater.