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. Author manuscript; available in PMC: 2018 Nov 20.
Published in final edited form as: Immunohorizons. 2018 Jan 1;2(1):27–37. doi: 10.4049/immunohorizons.1700073

Table I. Expression levels of transcripts encoding enzymes associated with arginine metabolism and the production of NO.

RNA-Seq
Sheep
 Goat
 Cattle
 Buffalo
Gene Name Description 0 h 7 h 0 h 7 h 0 h 7 h 0 h 7 h
ARG1 Arginase 1     0.04     0.05     2.64     2.73       6.05       5.84     0.02     0.01
ARG2 Arginase 2     7.40   56.27   11.82   41.06     48.48   347.99   30.06 153.54
ASL Argininosuccinate lyase   31.48   14.75   25.40   17.78     38.21     17.99   19.72     6.50
ASS1 Argininosuccinate synthase 1   19.39   10.18     4.38     3.72     10.71       7.65     0.05     0.32
GCH1 GTP cyclohydrolase 1   17.14   32.88     8.31   10.15     22.94     86.98   13.66   10.90
NOS2 NO synthase 2, inducible     0.55   19.09     3.78   19.69       2.14   901.20     3.25 301.37
OAT Ornithine aminotransferase 362.00 324.62 164.61 167.15 1166.67   854.75 204.40 142.74
ODC1 Ornithine decarboxylase 1   92.12 269.73 340.63 376.01     45.46     18.26 119.02   53.83
PTS 6-pyruvoyltetrahydropterin synthase   17.49   13.66   62.01   62.61     27.53     11.91   36.36   16.32
SLC3A2 Solute carrier family 3, member 2 161.19 167.79 209.91 210.11     98.20     62.87 168.22 146.74
SLC7A1 Solute carrier family 7, member 1     7.91   10.02   38.08   45.94       7.37       6.99   19.95   49.59
SLC7A2 Solute carrier family 7, member 2     0.01     0.04     5.88   15.73       0.04       0.18     0.18     2.03
SLC7A5 Solute carrier family 7, member 5     9.01   21.67 115.47 106.67       5.83       3.46     7.74     7.46
SLC7A7 Solute carrier family 7, member 7 283.90 161.32 109.13   60.78   220.58   120.25 114.72 103.68
SPR Sepiapterin reductase   21.00   13.80   78.29 124.30     20.47       4.60   37.28   13.15
RNA-Seq CAGE
Horse Pig Rat Human
Gene Name Description 0 h 7 h 0 h 7 h 0 h 7 h 0 h 7 h
ARG1 Arginase 1     0.10     0.05   70.62 379.11     76.63 1041.60     0.00     0.00
ARG2 Arginase 2 119.23   59.72   13.56   11.91       3.35       1.88     3.10     1.30
ASL Argininosuccinate lyase   24.06   14.48   13.93   10.35     69.63     50.24     5.80     0.70
ASS1 Argininosuccinate synthase 1   25.85   20.34     0.02     0.04       2.38   250.12     0.00     0.00
GCH1 GTP cyclohydrolase 1   24.77   31.89     9.82     9.67     24.17   189.57     0.70 391.00
NOS2 NO synthase 2, inducible     0.00     0.01     0.66     1.77     59.03 4961.79     0.00     0.00
OAT Ornithine aminotransferase 103.56   68.81   95.74   83.74   104.93     82.10   83.00   57.00
ODC1 Ornithine decarboxylase 1   98.48   39.73 241.26 195.93     64.55     45.63     5.30     1.30
PTS 6-pyruvoyltetrahydropterin synthase   27.98   16.30 143.49 141.30     11.51     13.01     0.50     0.00
SLC3A2 Solute carrier family 3, member 2 168.35 120.18 238.46 248.84   191.23   289.86 115.00 123.00
SLC7A1 Solute carrier family 7, member 1   13.27     9.72     5.45     4.68     20.02     14.00     0.00     0.00
SLC7A2 Solute carrier family 7, member 2     0.01     0.05     1.00     0.47     46.31   843.81     0.00     0.00
SLC7A5 Solute carrier family 7, member 5     8.97     7.28   13.09     8.81     17.71     14.76     2.70   75.00
SLC7A7 Solute carrier family 7, member 7   57.12   46.60 136.68 198.99     16.97     16.00   71.00   25.00
SPR Sepiapterin reductase   10.20     3.55   13.08     8.26     10.08       9.95   21.00     1.80

Expression levels are represented as TPM, and are mean values for each condition from multiple animals. Sheep, n = 6; goat, n = 3; buffalo, n = 4; cattle, n = 4; horse, n = 3; pig, n = 3; rat, n = 3; human, n = 3. Human data were generated by CAGE-seq, as previously described (10), and all other data were generated by RNA-seq as described.