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. 2018 Nov 19;37:277. doi: 10.1186/s13046-018-0948-3

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© The Author(s). 2018

Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 6 — Therapeutic efficacy of CKI on the patient-derived xenograft model of acute myeloid leukaemia. a The schematic diagram for the AML PDX model. b Analysis of bone marrow smear. At day 20, the bone marrow smear was stained and leukaemia cells were observed. Magnification fold: × 100 under an oil immersion lens. c The changes in body weight. d The survival analysis. e The remission state of bone marrow in the CKI group. f The immunophenotype of leukaemia cells in peripheral blood by flow cytometry analysis. g Statistics for the ratio of leukaemia cells. h The tissue weight index. i Testing the T-AOC vitality, GSH content, H₂O₂ concentration and CAT activity in plasma from B-NSG mice. j Detection of Prdx3, Prdx2, and Trx1 expression by IHC in the PDX model. k The model for the anti-leukaemic effects of CKI