Skip to main content
. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: J Immunol. 2018 Aug 13;201(7):1994–2003. doi: 10.4049/jimmunol.1800235

Figure 1. Rapid follicle formation and development of GC Tfh cells in lymph nodes of normal neonatal macaques.

Figure 1.

(A) B-cell follicle formation in lymph nodes of normal developing infants as detected by immunohistochemistry for CD20 (B cells); (B) Distribution and dynamics of PD-1 positive cells (Tfh) in germinal centers of lymph nodes of normal neonates with age; (C) Representative flow cytometry dot plots of PD-1high gated CD4+ T cells obtained from lymph nodes of normal infants at 0, 14, 28 and 180 days of age; (D) Levels of plasma CXCL13 in infants with age at day 0 (n=5), 7 (n=3), 14 (n=5), 21 (n=5), 28 (n=4), 42 (n=4), 90 (n=4), 180 (n=5) after birth, compared to adults (n=16). (E) Distribution and localization of GC Tfh cells (CXCR5+PD-1high CD4 T cells) in developing neonates with age showing lymph nodes from newborns (n=5), 1 month (n=4) and 6 months (n=5) after birth. *p<0.05, as compared with newborns. Data are presented as means ± s.e.m (C and D).