Organ Involvement	Manifestation
Constitutional	Fatigue Mild cognitive disturbance
Musculoskeletal	Arthritis/arthralgia Myositis (especially inclusion body myositis)
Cutaneous	Annular erythema Xerosis Palpable purpura
Pulmonary	Interstitial pneumonitis Follicular bronchiolitis
Vascular	Raynaud Vasculitis
Gastrointestinal	Atrophic gastritis Primary biliary cirrhosis
Endocrine	Autoimmune thyroid disease
Cardiac	Pericarditis
Renal	Interstitial nephritis with renal tubular acidosis Membranoproliferative glomerulonephritis
Hematologic	Leukopenia, neutropenia Thrombocytopenia Anemia Monoclonal gammopathy Cryoglobulinemia
Lymphoproliferative	Lymphoma
Neurologic	Peripheral neuropathy Ataxic ganglionopathy Myelitis (including neuromyelitis optica)