Table 2.

Concentrations for particles of sizes between 60-1000 nm (10⁸/mL) in IVIG solution centrifuged at various g forces and incubated at either 25° C or at 50° C

	45 minutes @2,350g	45 minutes @30,000g	3 hours @112,000g
Incubation at 25° C
Day 0		0.64	0.29
Day 1		0.32 ± 0.15	1.96 ± 1.15
Day 2	n/aa	0.29 ± 0.27	1.93 ± 1.13
Day 3		0.42 ± 0.19	0.63 ± 0.22
Day 4		0.55 ±0.10	1.33 ± 0.62
Day 5		1.76 ± 2.10	1.18 ±0.41
Incubation at 50° C
Day 0		4.1	1.28
Day 1		4.49 ± 0.27	0.71 ± 0.26
Day 2	n/aa	4.19 ± 1.59	1.02 ± 0.68
Day 3		2.35 ± 2.28	0.37 ± 0.14
Day 4		1.90 ± 0.24	0.08 ± 0.06
Day 5		1.80 ± 0.82	0.76 ± 0.48

^*Measurement error represents standard deviation from measurement of three independent samples

^aParticle levels above the upper limit of quantitation of the instrument (ca 10⁹ particles/mL)