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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: J Neural Transm (Vienna). 2018 Sep 27;125(11):1553–1566. doi: 10.1007/s00702-018-1927-8

Fig. 10. MAO A inhibitor-near infrared dye conjugate inhibits the growth of hu5man prostate tumor xenograft in mice.

Fig. 10

The structure of NIR dye−MAO A inhibitor conjugate (NMI) comprised of clorgyline and a near-infrared (NIR) dye is shown. (upper right panel) In vivo NIR imaging of the whole body clearly shows NMI localization within the tumor. Mice bearing C4–2B tumor xenografts were intraperitoneally injected with NMI (50 nmol/mouse) and subjected to NIR imaging 24 h later. (lower right panel) NMI inhibits the growth of C4–2B tumor xenografts in mice. C4–2B cells were subcutaneously injected into male nude mice (n = 5 for each group) to establish tumor xenografts. After tumor size reached 200 mm3, mice were given intratumoral treatments (saline and NMI; 750 nmol/mouse) every other day for a 21-day period. (Adapted from Wu et al., 2015)