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. Author manuscript; available in PMC: 2019 Nov 1.
Published in final edited form as: J Neural Transm (Vienna). 2018 Sep 27;125(11):1553–1566. doi: 10.1007/s00702-018-1927-8

Fig. 4. pCPA treatment during P1 to P7 rescued the autistic-like behaviors in adult MAO A KO mice.

Fig. 4

Effects of pCPA treatment from postnatal day 1 through 7 on (A) marble-burying behavior and (B) spontaneous alternations in a T-maze of MAO A KO mice. pCPA, an inhibitor of trypophan hydroxylase that reduces 5-HT level, was injected (30 mg/kg/day, IP) daily from P1 to P7. Values represent mean ±SEM; *P<0.05, ***P<0.001 compared to untreated wild-type mice; #P<0.05, ###P<0.001 compared to untreated MAO A deficient mice; †P<0.05, ††P<0.01 compared to untreated saline-treated MAO A KO mice; δδP<0.01, δP<0.05 compared to saline treated wild-type mice. (Adapted from Bortolato et al., 2013b)