Fig. 8. MAO A gene knockdown in human prostate cancer cells (LNCaP) significantly reduced cultured stem cell spheroid size and number.
Light microscope view of spheroid culture with prostate cancer cells expressing a scrambled shRNA (shControl, left side panel) versus a MAO A-targeting shRNA (shMAO A, right side panel). Loss of MAO A gene function reduced the size of spheroids formed after 12 days of culture in 3D Matrigel. Bar, 100 μm. (Adapted from Liao et al., 2018)