Table 2.
Density and distribution of Tau immunopositivity in Cases with mixed primary FTLD-TDP with FTLD-tau and density and distribution of phospho TDP-43 in Cases with mixed primary FTLD-tau with FTLD-TDP
| Primary FTLD-TDP mixed with FTLD- tau Pathology | Primary FTLD-tau mixed with FTLD-TDP Pathology | ||||||||
|---|---|---|---|---|---|---|---|---|---|
| Tau pathology | TDP pathology | ||||||||
| Case | 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | 9 |
| Primary diagnosis | TDP- A | TDP- B | TDP- B | TDP- C | TDP- C | CBD | CBD | CBD | CBD |
| Anterior cingulate cortex | 0 | 3 | 3 | 1 | 3 | 1 | 2 | 0 | |
| Middle frontal gyrus | 1 | 3 | 3 | 3 | 1 | 2 | 1 | 2 | 2 |
| Inferior frontal gyrus | 2 | 1 | 1 | 1 | 2 | 1 | |||
| Subgenual cingulate cortex | 1 | 1 | |||||||
| Precentral gyrus | 2 | 1 | 2 | 0 | 2 | ||||
| Superior frontal sulcus | 2 | 1 | |||||||
| Middle insula | 2 | 3 | 3 | 2 | 1 | ||||
| Entorhinal cortex (ERC) | 3 | 3 | 3 | 2 | 3 | 3 | 1 | 1 | |
| Inferior temporal gyrus | 3 | 3 | 3 | 1 | 2 | 1 | 1 | ||
| Superior temporal gyrus | 3 | 2 | 2 | ||||||
| Postcentral gyrus | 0 | 1 | 1 | 2 | 0 | ||||
| Posterior cingulate cortex (PCC) | 1 | 1 | 1 | 1 | |||||
| Angular gyrus | 1 | 3 | 3 | 1 | |||||
| Striate cortex | 0 | 1 | 0 | 0 | 0 | ||||
| Amygdala | 3 | 3 | 2 | 3 | 2 | 1 | |||
| Dentate gyrus | 0 | 3 | 2 | 1 | 1 | 1 | 0 | 1 | |
| CA3–4 | 1 | 3 | 1 | 2 | 1 | 2 | 0 | 2 | |
| CA2 | 1 | 2 | 3 | 3 | 1 | 2 | 0 | 2 | |
| CA1/Subculum | 2 | 3 | 2 | 3 | 2 | 2 | 2 | ||
| Ventral striatum | 2 | 1 | |||||||
| Putamen | 1 | 3 | 3 | 3 | 1 | ||||
| Globus Pallidus | 2 | ||||||||
| Claustrum | 1 | 3 | 3 | 2 | 0 | ||||
| Subthalamic nucleus | |||||||||
| Cerebellum (DN) | 0 | 1 | 0 | ||||||
| Midbrain (SN) | 1 | 2 | 1 | 2 | 3 | 2 | |||
| Pons (LC) | 0 | 1 | 3 | ||||||
| Medulla (Hypoglossal) | 0 | ||||||||
| Spinal Cord | 1 | ||||||||
Abbreviations. CA: Cornu ammonis, FTLD: frontotemporal lobar degeneration, TDP: TAR-DNA binding protein 43,
Each region was neuropathologically assessed based on the semiquantitative scale from 0 (none), 1 (mild), 2 (moderate), to 3 (severe) and each score in each region represents the maximum score out of the each neuropathological elements’ scores. Tau elements include neuronal cytoplasmic inclusions (NCIs), glial cytoplasmic inclusions (GCIs), gray matter threads, white matter threads, neurofibrillary tangles, globose tangles, tufted astrocytes, astrocytic plaques, thorny astrocytes and pick bodies. As for TDP proteinopathy, NCIs, GCIs, gray matter threads and dots, white matter threads and dots, dystrophic neurites, neuronal intranuclear inclusions (NIIs) are included as the TDP elements.