Table 2.
Drug acquisition costs
| Drug (brand) | Drug (generic) | Dose (mcg) | Pack size | Pack cost (PTP + VAT)a [26] Pack cost (PTP + VAT)a [26] | Dosing | Annual acquisition costa |
|---|---|---|---|---|---|---|
| Comparator drug costs | ||||||
| Spiolto Respimat | TIO/OLO | 5/5 | 30 doses (60 pulsations) | €81.49 | 2 inhalations once daily | €992 |
| Anoro Ellipta | UMEC/VI | 62.5/25 | 30 doses | €70.25 | 1 inhalation once daily | €855 |
| Subsequent treatment and other drugs costs | ||||||
| Spiriva Handihalerb | TIO | 18 | 30 doses | €49.06 | 1 inhalation once daily | €597 |
| Seretide Accuhalerb | SAL/FP | 50/500 | 60 doses | €41.28 | 1 inhalation twice daily | €503 |
| Flixotide Accuhalerc | FP | 500 | 60 doses | €31.47 | 2 inhalations once daily | €383 |
| Ventolind | Salbutamol | 100 | 200 doses | €2.69 | Based on head-to-head study [25]Based on head-to-head study [25] | |
aSource: Pack cost is taken from the Ministerio de Sanidad, Servicios Sociales e Igualdad. Available at: https://www.msssi.gob.es/en/home.htm Accessed February 2018
bTIO + SAL/FP administered together as escalation treatment for both UMEC/VI and TIO/OLO arm in base case
cadded on to UMEC/VI in an escalation strategy tested in a sensitivity analysis
drescue medication, modeled based on data from the head-to-head study [25]: 1.77 dose inhalations per day for TIO/OLO, 1.51 dose inhalations per day for UMEC/VI
FP fluticasone propionate, PTP price to public, SAL salmeterol xinafoate, TIO/OLO tiotropium/olodaterol, UMEC/VI umeclidinium/vilanterol, VAT value added tax