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. 2018 Nov 13;7:e37851. doi: 10.7554/eLife.37851

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© 2018, Ng et al

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Figure 7. — Bcl11b activation requires two rate-limiting steps: a switch of the Bcl11b locus from an inactive to active epigenetic state, and the activation of a trans factor is necessary for transcription of Bcl11b from an activated locus. Notch signaling activates TCF-1 and GATA3 in early thymic progenitors (García-Ojeda et al., 2013; Scripture-Adams et al., 2014; Weber et al., 2011), and these two factors may act on the identified distal enhancer to control the rate-limiting cis step on the Bcl11b locus (green). In parallel, Notch promotes the activation of a trans factor (red) that is necessary for transcription from a cis-activated Bcl11b locus. The cis and trans-limiting steps together control the dynamics of Bcl11b expression and T-cell lineage commitment.