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. 2018 Nov 20;9:81. doi: 10.1186/s40104-018-0297-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Functional analysis of DEGs found in the D3-D1 comparison obtained using Cytoscape. Significant terms are graphically summarized using REVIGO or manually according to the REACTOME database. The figure shows the hub DEGs and the interactions with their related pathways and BPs. Legend: squares = pathways; circles = biological processes (BPs); shape size = according to the P-value of the term in its own group; red colour = upregulated (cluster #1); green colour = downregulated (cluster #2); fill colour transparency = according to the percentage of genes belonging to the cluster; font size = according to the P-value of the term in its own group; interaction line thickness = according to kappa score value, represents the strength of the interactions, lighter colour corresponds to a lower strength while darker colour to a higher strength