Table 4.

Association between use of acetaminophen by mother during pregnancy and mental health outcomes at the age of 11 years among boys (N = 1781) and girls (N =  1666)

Outcomes	Frequency of outcome according to use of acetaminophen during pregnancy N (%)		Crude analysis	Adjusted analysisa
	Exposed n (%)	Not exposed n (%)	OR (95% CI)	OR (95% CI)	p
Boys
Total SDQ (score ≥ 17 pts)	89 (17.05)	199 (15.81)	1.09 (0.83–1.44)	1.21 (0.89–1.64)	0.228
Emotional symptoms (score ≥ 5 pts)	116 (22.22)	223 (17.71)	1.33 (1.03–1.71)	1.31 (0.99–1.73)	0.052
Conduct problems (score ≥ 4 pts)	68 (13.03)	185 (14.69)	0.87 (0.64–1.17)	1.08 (0.77–1.51)	0.664
Hyperactivity/inattention (score ≥ 7 pts)	115 (22.03)	252 (20.02)	1.13 (0.88–1.45)	1.25 (0.95–1.65)	0.115
Peer relationship problems (score ≥ 4 pts)	78 (14.94)	191 (15.17)	0.98 (0.74–1.31)	1.16 (0.85–1.59)	0.339
Prosocial behavior (score ≤ 4 pts)	3 (0.57)	25 (1.99)	0.29 (0.86–0.95)	0.47 (0.14–1.63)	0.234
Girls
Total SDQ (score ≥ 17 pts)	49 (11.21)	143 (11.64)	0.95 (0.68–1.35)	1.16 (0.80–1.69)	0.426
Emotional symptoms (score ≥ 5 pts)	97 (22.20)	250 (20.34)	1.12 (0.85–1.46)	1.08 (0.81–1.43)	0.624
Conduct problems (score ≥ 4 pts)	40 (9.15)	158 (12.86)	0.68 (0.47–0.98)	0.77 (0.52–1.14)	0.192
Hyperactivity/inattention (score ≥ 7 pts)	50 (11.44)	139 (11.31)	1.01 (0.72–1.43)	1.14 (0.79–1.64)	0.498
Peer relationship problems (score ≥ 4 pts)	53 (12.13)	137 (11.15)	1.10 (0.78–1.54)	1.30 (0.90–1.89)	0.164
Prosocial behavior (score ≤ 4 pts)	5 (1.14)	15 (1.22)	0.94 (0.34–2.59)	1.38 (0.47–4.07)	0.562

^aLogistic regression adjusted according to maternal age, parity, national economic index, maternal educational level, smoking during pregnancy, alcohol comsumption during pregnancy, maternal skin color, infection during pregnancy, pre-gestational BMI, presence of maternal mood issue and use of other analgesics during pregnancy. N after adjustment: 1585 boys and 1494 girls