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. 2018 Nov 19;19:328. doi: 10.1186/s12882-018-1128-6

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Flowchart of analyzed patients. A total of 337 patients with biopsy-proven IgAN entered the run-in phase of the STOP-IgAN trial during which all patients received supportive care. After 6 months, 162 patients were randomized to either continue on supportive care (n = 80) or received additional immunosuppression (n = 82). Upon amendment of the initial trial protocol in 2009, we aimed to retrieve the original kidney biopsies from the randomized patients for the current secondary analysis. Eventually, 70 biopsies were collected and could be scored using the MEST-C criteria