Fig 5. Adjusted stimulation signal by FAS protocol.
The frequency of the DBS signal is modulated based on the feedback control signal (blue line). Peaks of the control signal indicate high synchronization and therefore, HFS DBS is used for maximum therapeutic effects. With lower amplitudes of the control signal, the urge for HFS decreases and IDBS is then adapted to lower frequencies. The cathodic and anodic peaks of the stimulus signal were set to 100 μA and -10 μA, respectively. The control signal is magnified 100 times for better clarification.