Table 3.
Associations between PD-L1, pSTAT3 and other clinicopathologic factors in diffuse large B cell lymphoma (n = 107)
| PD-L1i | PD-L1 translocation (A) | PD-L1 gain/amplification (B) | PD-L1 gene alteration (A + B) | PD-L1 non-genetic expressionb | pSTAT3a (continuous) | pSTAT3 (> 40%) | |
|---|---|---|---|---|---|---|---|
| PD-L1t | R = 0.325 p = 0.001 |
R = 0.477 p < 0.001 |
R = 0.386 p < 0.001 |
R = 0.629 p < 0.001 |
R = 0.698 p < 0.001 |
R = 0.079 p = 0.429 |
R = 0.071 p = 0.466 |
| PD-L1i | R = 0.239 p = 0.015 |
R = 0.159 p = 0.109 |
R = 0.291 p = 0.003 |
R = 0.166 p = 0.092 |
R = 0.081 p = 0.414 |
R = 0.015 p = 0.879 |
|
| PD-L1 translocation (A) | R = − 0.051 p = 0.614 |
R = 0.758 p < 0.001 |
R = − 0.090 p = 0.364 |
R = − 0.049 p = 0.628 |
R = − 0.037 p = 0.714 |
||
| PD-L1 gain/amplification (B) | R = 0.613 p < 0.001 |
R = − 0.073 p = 0.464 |
R = − 0.117 p = 0.242 |
R = − 0.072 p = 0.470 |
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| PD-L1 gene alteration (A + B) | R = − 0.120 p = 0.228 |
R = − 0.117 p = 0.245 |
R = − 0.021 p = 0.835 |
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| PD-L1 non-genetic expressionb | R = 0.205 p = 0.033 |
R = 0.120 p = 0.224 |
Correlation coefficients (R) and p values by Pearson’s correlation
a Indicates the proportion (%) of tumor cells expressing pSTAT3 by using digital image analyzer
b Indicates PD-L1t+ cases with no alteration (translocation or gain/amplification) of PD-L1 gene