Table 4.
Associations between genetic alteration and protein expression status of PD-L1 and primary sites
| Primary site | GI | Testis | Adrenal gland | ||||||
|---|---|---|---|---|---|---|---|---|---|
| Non-GI | GI | p value | Non-testis | Testis | p value | Non-adrenal | Adrenal | p value | |
| PD-L1t | |||||||||
| Absent | 67 | 17 | 0.354 | 74 | 10 | 0.494 | 83 | 1 | 0.116 |
| Present | 21 | 2 | 19 | 4 | 21 | 2 | |||
| PD-L1i | |||||||||
| Absent | 55 | 14 | 0.435 | 59 | 10 | 0.766 | 68 | 1 | 0.287 |
| Present | 33 | 5 | 34 | 4 | 36 | 2 | |||
| PD-L1 translocation (A) | |||||||||
| Absent | 80 | 18 | 0.587 | 87 | 11 | 0.031 | 95 | 3 | 1.000 |
| Present | 6 | 0 | 3 | 3 | 6 | 0 | |||
| PD-L1 gain/amplification (B) | |||||||||
| Absent | 81 | 19 | 1.000 | 87 | 13 | 0.444 | 98 | 2 | 0.112 |
| Present | 4 | 0 | 3 | 1 | 3 | 1 | |||
| PD-L1 genetic alteration (A + B) | |||||||||
| Absent | 75 | 18 | 0.203 | 83 | 10 | 0.029 | 91 | 2 | 0.266 |
| Present | 10 | 0 | 6 | 4 | 9 | 1 | |||
p values were calculated by using Fisher’s exact test (2-sided)
GI: gastrointestinal; GA: genetic alteration