Table 1.
Probe (ID) | miRNA gene | Genomic functional distribution | CpG context | Internal data | TCGA data | ||||
---|---|---|---|---|---|---|---|---|---|
Delta β | P | P adj. | Delta β | P | FDR | ||||
cg19019198 | MIRLET7G | TSS200 | − 0.36 | < 1e-07 | < 1e-07 | − 0.49 | < 1e-07 | < 1e-07 | |
cg07181702 | MIR21 | Body | − 0.19 | < 1e-07 | < 1e-07 | − 0.20 | < 1e-07 | < 1e-07 | |
cg04276626 | MIR21 | TSS200 | − 0.18 | < 1e-07 | < 1e-07 | − 0.16 | < 1e-07 | < 1e-07 | |
cg02515217 | MIR21 | TSS200 | − 0.17 | < 1e-07 | < 1e-07 | − 0.16 | < 1e-07 | < 1e-07 | |
cg15759721 | MIR21 | Body | − 0.17 | < 1e-07 | < 1e-07 | − 0.14 | < 1e-07 | < 1e-07 | |
cg04805065 | MIR33B | TSS1500 | Shore | − 0.25 | < 1e-07 | < 1e-07 | − 0.29 | < 1e-07 | < 1e-07 |
cg09186408 | MIR33B | TSS1500 | Shore | − 0.20 | < 1e-07 | < 1e-07 | − 0.23 | < 1e-07 | < 1e-07 |
cg19619576 | MIR33B | TSS1500 | Shelf | − 0.16 | < 1e-07 | 1e-07 | − 0.21 | < 1e-07 | < 1e-07 |
cg01243312 | MIR128–1 | Body | 0.20 | < 1e-07 | < 1e-07 | 0.23 | < 1e-07 | < 1e-07 | |
cg10734581 | MIR134 | TSS1500 | − 0.19 | < 1e-07 | < 1e-07 | NA | NA | NA | |
cg15857661 | MIR146B | TSS200 | Shelf | − 0.33 | < 1e-07 | < 1e-07 | − 0.34 | < 1e-07 | < 1e-07 |
cg05858126 | MIR146B | TSS200 | Shelf | − 0.32 | < 1e-07 | < 1e-07 | − 0.33 | < 1e-07 | < 1e-07 |
cg05251190 | MIR146B | TSS200 | Shelf | − 0.30 | < 1e-07 | < 1e-07 | − 0.29 | < 1e-07 | < 1e-07 |
cg13442016 | MIR146B | Body | Shelf | − 0.29 | < 1e-07 | < 1e-07 | − 0.29 | < 1e-07 | < 1e-07 |
cg09701700 | MIR146B | TSS1500 | Shelf | − 0.20 | < 1e-07 | < 1e-07 | − 0.19 | < 1e-07 | < 1e-07 |
cg13309012 | MIR155 | Body | − 0.30 | < 1e-07 | < 1e-07 | − 0.30 | < 1e-07 | < 1e-07 | |
cg13449535 | MIR200B | TSS1500 | Shore | − 0.25 | < 1e-07 | < 1e-07 | − 0.37 | < 1e-07 | < 1e-07 |
cg14144728 | MIR200B | TSS1500 | Shore | − 0.23 | < 1e-07 | < 1e-07 | − 0.21 | < 1e-07 | < 1e-07 |
cg08096702 | MIR211 | TSS1500 | − 0.29 | < 1e-07 | < 1e-07 | − 0.34 | < 1e-07 | < 1e-07 | |
cg11721554 | MIR377 | TSS1500 | Shelf | − 0.17 | < 1e-07 | < 1e-07 | − 0.20 | < 1e-07 | < 1e-07 |
cg05138957 | MIR377 | TSS1500 | Shelf | − 0.15 | < 1e-07 | < 1e-07 | − 0.19 | < 1e-07 | < 1e-07 |
cg21513316 | MIR410 | Body | Island | − 0.16 | < 1e-07 | < 1e-07 | − 0.14 | < 1e-07 | < 1e-07 |
cg20547131 | MIR412 | TSS1500 | Shore | − 0.17 | < 1e-07 | < 1e-07 | − 0.15 | < 1e-07 | < 1e-07 |
cg14910227 | MIR495 | Body | − 0.19 | < 1e-07 | < 1e-07 | − 0.27 | < 1e-07 | < 1e-07 | |
cg11978784 | MIR512–1 | TSS1500 | − 0.17 | < 1e-07 | < 1e-07 | NA | NA | NA | |
cg10583119 | MIR518D | TSS1500 | − 0.18 | < 1e-07 | < 1e-07 | − 0.22 | < 1e-07 | < 1e-07 | |
cg17670263 | MIR520C | TSS1500 | − 0.21 | < 1e-07 | 1e-07 | − 0.27 | < 1e-07 | < 1e-07 | |
cg05865548 | MIR543 | TSS200 | − 0.16 | < 1e-07 | < 1e-07 | − 0.22 | < 1e-07 | < 1e-07 | |
cg04522625 | MIR548A2 | Body | 0.24 | < 1e-07 | < 1e-07 | 0.30 | < 1e-07 | < 1e-07 | |
cg18697991 | MIR548A2 | Body | 0.19 | < 1e-07 | < 1e-07 | 0.20 | < 1e-07 | < 1e-07 | |
cg03221073 | MIR548F1 | Body | − 0.41 | < 1e-07 | < 1e-07 | − 0.34 | < 1e-07 | < 1e-07 | |
cg25874148 | MIR548F5 | Body | − 0.28 | < 1e-07 | < 1e-07 | NA | NA | NA | |
cg01719718 | MIR548F5 | Body | − 0.17 | < 1e-07 | 2e-07 | − 0.18 | < 1e-07 | < 1e-07 | |
cg05878887 | MIR548G | Body | − 0.31 | < 1e-07 | < 1e-07 | − 0.33 | < 1e-07 | < 1e-07 | |
cg21175685 | MIR548G | Body | − 0.31 | < 1e-07 | < 1e-07 | − 0.24 | < 1e-07 | < 1e-07 | |
cg02145866 | MIR548G | Body | − 0.29 | < 1e-07 | < 1e-07 | − 0.30 | < 1e-07 | < 1e-07 | |
cg26664528 | MIR548H4 | Body | Shore | − 0.28 | < 1e-07 | < 1e-07 | NA | NA | NA |
cg11539052 | MIR548N | Body | Shore | − 0.20 | < 1e-07 | < 1e-07 | NA | NA | NA |
cg05966699 | MIR567 | TSS1500 | − 0.16 | < 1e-07 | < 1e-07 | − 0.24 | < 1e-07 | < 1e-07 | |
cg06277638 | MIR570 | TSS1500 | − 0.17 | < 1e-07 | < 1e-07 | NA | NA | NA | |
cg09031823 | MIR575 | TSS1500 | − 0.17 | < 1e-07 | 7e-04 | − 0.25 | < 1e-07 | < 1e-07 | |
cg18948646 | MIR575 | TSS200 | − 0.16 | < 1e-07 | < 1e-07 | − 0.13 | < 1e-07 | < 1e-07 | |
cg26620021 | MIR641 | TSS1500 | Shore | − 0.28 | < 1e-07 | < 1e-07 | NA | NA | NA |
cg11035122 | MIR758 | TSS1500 | − 0.15 | < 1e-07 | 2e-06 | − 0.18 | < 1e-07 | < 1e-07 | |
cg02558026 | MIR762 | TSS1500 | Shore | − 0.20 | < 1e-07 | < 1e-07 | − 0.24 | < 1e-07 | < 1e-07 |
cg13204193 | MIR942 | Body | 0.19 | < 1e-07 | < 1e-07 | NA | NA | NA | |
cg01940297 | MIR1207 | TSS1500 | 0.16 | < 1e-07 | 3e-06 | 0.25 | < 1e-07 | < 1e-07 | |
cg25037841 | MIR1286 | TSS1500 | 0.15 | < 1e-07 | < 1e-07 | 0.18 | < 1e-07 | < 1e-07 | |
cg25591377 | MIR1288 | TSS1500 | − 0.27 | < 1e-07 | < 1e-07 | − 0.24 | < 1e-07 | < 1e-07 | |
cg02746110 | MIR1301 | TSS1500 | 0.16 | < 1e-07 | 4e-07 | 0.18 | < 1e-07 | < 1e-07 |
NA probes not available in the TCGA processed data (level 3); P Adj Bonferroni P value; FDR false discovery ratio; TSS transcription start sites; Shelf, 2–4 kb from CpG island; Shore, until 2 kb from CpG island