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. 2018 Nov 20;19:828. doi: 10.1186/s12864-018-5201-0

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Exosomal miRNAs expression profiles during lactation period. a Hierarchical clustering analysis for the normalized expression of conserved miRNAs among seven exosomal miRNA libraries based on Euclidean distance. b The number of expressed miRNAs at the two major stages and three early stages. c Top 10 miRNAs with the highest expression levels in exosomal miRNA libraries. Box Plot with different color represents the percentage of each miRNA expression in each library. Four co-expressed miRNAs in all 5 lactation stages are connected by lines (cli-miR-148a-3p, a potential biomarker for the quality control of mammalian milk can be seen marked with red line)