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. 2018 Nov 20;19:826. doi: 10.1186/s12864-018-5219-3

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Heatmap of linkage disequilibrium (LD) values (R²) between candidate SNPs in the CHRNA5/A3/B4 locus. Pairwise LD values (Caucasians) were calculated between candidate variants selected by GWAS hits/eQTLs overlap, top eQTLs, and regulatory regions in the CHRNA5/A3/B4 nicotinic receptor locus. On the basis of pairwise LD (R²), the candidate SNPs were grouped into four distinct LD blocks; cluster 1 to 4. The heatmap is independent of genomic location of each SNP