Table 4.
Pharmacokinetic parameters for 42, 76, and 81
| Parameter | Unit | 42 | 76 | 81 |
|---|---|---|---|---|
| Lambda_z | 1/h | 0.18 | 0.079 | 0.074 |
| t1/2 | h | 3.87 | 8.83 | 9.39 |
| Tmax | h | 1 | 8 | 3 |
| Cmax | ng/ml | 5773.00 | 893.99 | 171.81 |
| Tlag | h | 0 | 0 | 0 |
| Clast_obs/Cmax | 0.00044 | 0.044 | 0.036 | |
| AUC 0-t | ng/ml*h | 51805.98 | 16599.23 | 2947.61 |
| AUC 0-inf obs | ng/ml*h | 51820.33 | 17101.39 | 3032.42 |
| AUC 0-t/0-inf_obs | 1.00 | 0.97 | 0.97 | |
| AUMC 0-inf obs | ng/ml*h^2 | 343077.41 | 270875.20 | 39656.44 |
| MRT 0-inf_obs | h | 6.62 | 15.84 | 13.08 |
| Vz/F_obs | (mg/kg)/(ng/ml) | 0.0011 | 0.0074 | 0.045 |
| Cl/F_obs | (mg/kg)/(ng/ml)/ h | 0.00019 | 0.00058 | 0.0033 |