Table 1.

Summary of known genomic and mutational data in aggressive B-cell lymphomas

Category	Associated genotype	Most frequent mutations
GCB-DLBCL	BCL2 or MYC translocations, DH or TH, complex karyotype, PTEN deletion	EZH2, GNA13, BCL6, TNFSR14, FOXO1, ACTB, SOCS1, BCL2, SGK1	KMT2D, CREBBP, EP300, TP53, HST1H1E/C, B2M
ABC-DLBCL	BCL2 amplifications, CDKN2A/B deletion, complex karyotype, rare DH or TH	MYD88, CD79A/B, CARD11, TNFAIP3, PIM1, NOTCH1, SPIB, PRDM1 (mutually exclusive with BCL6 rearrangements)	MHC class I, TP53, MEF2B, NOTCH 2, BTG1/2, SOCS1, DTX, SPEN, TNFAIP3, TMSB4X
UNC-DLBCL	Complex karyotype, NOTCH2 amplification, BCL6 translocations, rare MYC with BCL6 DH	NOTCH2
HG-DH/TH	DH or TH of MYC and BCL2 and/or BCL6
HGBL, NOS	No DH nor TH
BL	MYC rearrangement, 1q gains, no DH or TH, low complexity karyotype	TCF3, ID3
BLL with 11q alteration	11q alterations, no MYC rearrangement, no 1q gains