Table 2.
Studies reporting ICH in children and adults with ITP
| First author, year | Methodology | Subjects | ICH incidence (%) | ITP phase at ICH | Platelet count at ICH (×109/L) |
|---|---|---|---|---|---|
| Lilleyman, 199421 | Retrospective | Children | 14/∼11 000 (∼0.1) | 72% ND, 14% P, 14% C | <15 |
| Iyori, 200022 | Retrospective | Children | 4/772 (0.5) | 75% ND, 25% C | <10 |
| Kühne, 200113 | Prospective | Children | 2/1 496 (0.1) | ND* | |
| Neunert, 200823 201324 | Prospective | Children | 1/863 (0.1) [0-28 d]; 0/854 (0) [6-24 mo] | 100% ND, 0% P/C | <20 |
| Choudhary, 200925 | Retrospective | Children | 17/750 (2.3) | 59% ND, 41% C | Median, 12 (range, 20-50) |
| Psaila, 200926 | Retrospective | Children | 40 (0.19-0.78) | 45% ND, 25% P, 30% C | Median, 5 (<20 in 90%) |
| Elalfy, 201027 | Retrospective | Children | 10/1 840 (0.5) | 40% ND, 20% P, 40% C | <10 in 70% |
| Nørgaard, 201119 | Retrospective | Adults | 5/407 (1.2) | C* | <30 |
| Saeidi, 20148 | Retrospective | Children & adults | Children 0/223 (0); adults 0/100 (0) | N/A | N/A |
| Neunert, 201514 | Retrospective | Children & adults | Children (0.4); adults (1.4) | C (1.6%) > ND (0.4%) | |
| Zhou, 201528 | Retrospective | Children | 9/520 (1.7) | 45% ND, 22% P, 33% C | Median, 6 (<20 in 89%); range, 0-32 |
| Palandri, 201651 | Retrospective | Adults | 3/557 (0.5) | ||
| Altomare, 201618 | Retrospective | Adults | 74/6 651 (1.1) | ||
| Tsuda, 201720 | Retrospective | Adults | 5/169 (3) | <30 | |
| Schifferli, 20186 | Prospective | Children & adults | Children 20/3 360 (0.6); adults 7/420 (1.7) | 78% ND, 11% P, 11% C | <20 in 93% |
C, chronic; N/A, not available; ND, newly diagnosed; P, persistent.
*
Study population included only patients in this phase of disease.