Fig. 3. HE staining of various tissues from the BALB/c neonatal mice that were i.p. challenged with CV-B5/JS417.

a, c, e, g HE staining of cerebral cortex, spinal cord, myocardium, and hindlimb muscle tissues of the control group, respectively. b, d, f, h HE staining of corresponding tissues of the experimental group. b Necrosis of the cerebral cortex associated with tubular infiltration (arrow); d: degeneration and necrosis of spinal cord nerve cells with glial response (arrow); f: eosinophilic necrosis of cardiomyocytes (arrow); h: necrotic myositis of hindlimb muscle (arrow). Magnifications ×100 (a–c, e, g, h), Magnifications ×200 (d, f). n = 6–10 mice for each group. One representative image is shown