Table 1.

Inhibitory concentrations and cytotoxic concentrations of AR-12 and its derivatives in A549 cells

Virus	Compound	CC50 (µM)	IC50 (nM)	SI (CC50/IC50)
DENV-2-eGFP	AR-12	21.4 ± 0.2	660.5 ± 130	33.2 ± 5.9
	P12-23	20.5 ± 0.1	69.7 ± 8.9	296.7 ± 35.1
	P12-34	20.3 ± 0.2	52.1 ± 2	387.9 ± 14.7
JEV-eGFP	AR-12	21.4 ± 0.2	509.9 ± 52.4	42.3 ± 4.1
	P12-23	20.5 ± 0.1	53.2 ± 1.6	385.5 ± 11.8
	P12-34	20.3 ± 0.2	56.1 ± 0.5	360.3 ± 3.1
ZIKV	AR-12	21.4 ± 0.2	1373 ± 176.6	15.8 ± 2
	P12-23	20.5 ± 0.1	130.3 ± 11.7	158 ± 13.6
	P12-34	20.3 ± 0.2	118.6 ± 11.7	171.4 ± 16.1
DENV-1	P12-34	20.3 ± 0.2	98 ± 1.7	206.3 ± 3.5
DENV-2	P12-34	20.3 ± 0.2	62.2 ± 4.9	326.5 ± 26.4
DENV-3	P12-34	20.3 ± 0.2	90.6 ± 3.4	223.4 ± 8.6
DENV-4	P12-34	20.3 ± 0.2	63.9 ± 5.1	317.8 ± 24.9

CC₅₀ 50% cytotoxic concentration, IC₅₀ 50% inhibitory concentration, SI selectivity index = CC₅₀/IC₅₀