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. 2018 Nov 14;9:1161. doi: 10.3389/fphar.2018.01161

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Copyright © 2018 Lu, Sun, Chen, Qin and Guo.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The therapeutic roles by which Shexiang Baoxin Pills protect against cardiovascular diseases. SBP, Shexiang Baoxin Pill; VEGF, vascular endothelial growth factor; EPC, endothelial progenitor cell; eNOS, endothelial nitric oxide synthase; NO, nitric oxide; PPAR, peroxisome proliferator-activated receptor; AMPK, AMP-activated protein kinase; PGC-1α, peroxisome proliferator-activated receptor gamma coactivator 1-α; SOD, superoxide dismutase; MDA, malondialdehyde; ET-1, endothelin-1; α-SMA, α-smooth muscle actin; SM-MHC, smooth muscle myosin heavy chain; MMP-9, matrix metalloprotein 9; TIMP-1, tissue inhibitor of metalloproteinase 1; PRA, plasma rein activity; AT2R, angiotensin II type 2 receptor.