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. 2018 Nov 14;9:588. doi: 10.3389/fpsyt.2018.00588

Figure 4.

Figure 4

Injection of GALR1-siRNA into PFC reversed depressive-like behaviors. (A) A low magnification (10 ×) representative image of coronal brain sections showing the injection sites. The success of AAV vector injection into the PFC was confirmed by GFP fluorescence. (B) GALR1 mRNA level significantly decreased in the PFC after GALR1-siRNA treatment compared to PPD group and PPD + Scramble group. (C) Climbing time elevated to normal level after GALR1-siRNA treatment. (D) Immobility time significantly decreased in PPD + siRNA group compared to PPD groups. (E) Decreased sucrose consumption was reversed after GALR1-siRNA treatment. Data were represented as mean ± SEM (n = 6–8 in each group). *p < 0.05, **p < 0.01, ***p < 0.001 compared to PPD group; #p < 0.05, ##p < 0.01, ###p < 0.001 compared to PPD + Scramble group (A–C). ***p < 0.001 compared to Ctrl group. Data were analyzed by one-way ANOVA followed by post-hoc Tukey HSD multiple comparison tests. Scale bar = 50 0m.