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. 2018 Nov 21;38(6):BSR20180876. doi: 10.1042/BSR20180876

Figure 7. The hypothesis that the relative inadequency of autophagy and mitophagy is involved in contrast-induced TEC apoptosis and CI-AKI.

Figure 7

Contrast exposure causes mitochondrial injury (possibly through calcium influx), which activates autophagy and mitophagy. But, the activated autophagy and mitophagy are relatively inadequate for the large quantities of damaged mitochondria. So large quantities of damaged mitochondria accumulated in cytoplasm, which can further induce ROS and Cyt c release from the mitochondria and result in TEC apoptosis and CI-AKI. Enhancing autophagy help integrate the damaged mitochondria with membranes containing LC3 and accelerate the clearance of damaged mitochondria, which further alleviates the oxidative stress and ameliorates contrast-induced TEC apoptosis and CI-AKI.