Table 3. Univariable and multivariable Cox regression analysis of the three-lncRNA signature and overall survival in each dataset.

	Univariate analysis			Multivariate analysis
	HR	95% CI of HR	P-Value	HR	95% CI of HR	P-value
Training dataset (n=213)
Train score	2.718	2.016–3.666	5.54E-11	2.528	1.735–3.683	1.36E-06
Age (old/young)	1.035	0.648–1.654	0.884	0.860	0.499–1.482	0.588
Gender (male/female)	0.835	0.489–1.424	0.508	0.892	0.456–1.744	0.739
Pathologic stage (Stage III_IV/I_II)	1.558	0.864–2.808	0.140	1.536	0.751–3.145	0.240
Alcohol history documented (Yes/No)	1.027	0.629–1.676	0.915	0.992	0.548–1.796	0.979
pN (positive/negative)	0.735	0.334–1.615	0.443	0.709	0.238–2.114	0.537
Testing dataset (n=212)
Test score	1.457	1.093–1.942	0.010	2.224	1.194–4.139	0.012
Age (old/young)	1.540	0.947–2.505	0.082	1.210	0.655–2.236	0.543
Gender (male/female)	0.783	0.480–1.277	0.327	1.178	0.592–2.346	0.640
Pathologic stage (Stage III_IV/I_II)	1.476	0.773–2.817	0.238	2.169	0.870–5.407	0.097
Alcohol history documented (Yes/No)	0.795	0.489–1.293	0.355	0.806	0.404–1.609	0.541
pN (positive/negative)	0.542	0.292–1.007	0.053	0.215	0.089–0.516	0.001
Entire dataset (n=425)
Entire score	1.770	1.481–2.115	3.49E-10	2.096	1.574–2.790	4.02E-07
Age (old/young)	1.286	0.918–1.802	0.144	1.073	0.722–1.595	0.727
Gender (male/female)	0.837	0.588–1.192	0.325	1.124	0.704–1.796	0.624
Pathologic stage (Stage III_IV/I_II)	1.494	0.969–2.305	0.069	1.787	1.022–3.122	0.0418
Alcohol history documented (Yes/No)	0.893	0.633–1.258	0.516	0.842	0.542–1.310	0.446
pN (positive/negative)	0.640	0.396–1.034	0.068	0.356	0.182–0.695	0.002