Skip to main content
. Author manuscript; available in PMC: 2020 Feb 1.
Published in final edited form as: J Cell Physiol. 2018 Sep 10;234(2):1088–1098. doi: 10.1002/jcp.27265

Figure 6. Working model of HDAC inhibitor-mediated suppression of ERK and JNK phosphorylation and inflammatory gene expression.

Figure 6.

A) HDAC 2 regulates TNFα-induced ERK signaling. HDACs 1 and 2 in combination regulate TNFα-induced JNK phosphorylation. Inhibition of ERK and JNK partly explain anti-inflammatory mechanisms linked to class I selective HDAC inhibitors in bovine mammary epithelial cells (MAC-Ts). B) In addition, inhibition of HDACs attenuates pro-inflammatory gene expression through mechanisms associated with canonical regulation of gene expression, independent of MAPK signaling.