Table 3.
Log IL-6 Mediates the Relationship between T1 Anxiety and T3 Depression at Different Levels of Rumination (N=86)
| Variable | Coefficient | Standard Error | t | p |
|---|---|---|---|---|
| Outcome: a’ path (predicting to T2 Log IL-6) | ||||
| T1 Anxiety | −.0126 | .0055 | −2.2813 | .0254 |
| T1 Rumination | −.0155 | .0087 | −1.7750 | .0801 |
| T1 Log IL-6 | .4128 | .1032 | 4.0013 | .0001 |
| T1 Anxiety x T1 Rumination | .0004 | .0002 | 2.0702 | .0420 |
| T1 Depression | .0014 | .0053 | .2671 | .7901 |
| R2 accounted for | 44% | |||
| Outcome: b’ path (predicting to T3 Dep) | ||||
| T1 Anxiety | .0292 | .0317 | .9227 | .3592 |
| T1 Depression | .5350 | .0831 | 6.4366 | <.0001 |
| T1 Log IL-6 | −1.9508 | 1.9558 | −.9974 | .3218 |
| T2 Log IL-6 | 3.4101 | 2.0037 | 1.7019 | .0930 |
| R2 accounted for | 55% | |||
| Conditional indirect effect of T1 Anxiety on T3 Depression at Different Levels of Rumination: | ||||
| Rumination Percentile | Effect | Boot Standard Error | Boot LLCI | Boot ULCI |
| −1 SD | −.0178 | .0121 | −.0509 | −.0010 |
| Mean | −.0063 | .0078 | −.0327 | .0026 |
| +1SD | .0053 | .0089 | −.0078 | .0295 |
| Index of Moderated Mediation | ||||
| Mediator | Index | Boot Standard Error | Boot LLCI | Boot ULCI |
| T2 Log IL-6 | .0015 | .0009 | .0001 | .0039 |
Note: All analyses controlled for the effects of T1 age, T2 BMI, T2 time of blood draw, sex, race, whether the family qualified for a free school lunch, and months in study. IL- = Interleukin.