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. Author manuscript; available in PMC: 2019 Nov 9.
Published in final edited form as: Dev Dyn. 2018 Nov 9;247(11):1199–1210. doi: 10.1002/dvdy.24679

Figure 5 – neil3 knockdown embryos exhibit deficits in retinal development.

Figure 5 –

A – C. Knockdown of neil3 results in a disorganized retina. Histological staining of retinas from uninjected (A) or injected (B,C) sides of embryos injected with neil3 antisense morpholino oligonucleotide (ASMO), sectioned, and stained with hemotoxylin/eosin. D – F. Knockdown of neil3 results in aberrant retinal cell differentiation. Embryos injected with neil3 ASMO were fixed and subjected to immunohistochemistry using antibodies against Islet-1 (D,E) or rhodopsin (F,G). Panels D and F show uninjected side and E and G show injected sides. R – retinal pigmented epithelium (RPE); P – photoreceptor layer; I – inner nuclear layer (INL), G – ganglion cell layer; L – lens. Arrows indicate examples of putative photoreceptor rosettes.