Table 2.
Characteristics of geographic atrophy at first appearance and progression to neovascular AMD and central geographic atrophy
| Prevalence cohort: existing GA at baseline (without simultaneous or prior neovascular AMD) | Incidence cohort: new GA during follow-up (without simultaneous or prior neovascular AMD) | Combined cohort (combination of prevalence and incidence cohorts) | |
|---|---|---|---|
| Eyes | 517 | 1099 | 1616 |
| Mean (SD) BCVA at first appearance of GA (letters) (Snellen equivalent) | |||
| All GA | 67.5 (20.2) (20/50) | 75.4 (13.0) (20/30) | 69.7 (18.4) (20/40) |
| Central GA | 53.0 (24.6) (20/100) | 70.0 (15.8) (20/40) | 58.8 (22.2) (20/60) |
| Non-central GA | 74.6 (12.6) (20/30) | 78.1 (10.3) (20/30) | 74.9 (13.4) (20/30) |
| Mean (SD) size of GA at first appearance of GA (mm2) | 3.4 (4.2) | 1.7 (2.5) | 2.2 (3.2) |
| 1.3 DA (1.6 DA) | 0.7 DA (1.0 DA) | 0.9 DA (1.3 DA) | |
| Mean (SD) proximity of GA to central macula at first appearance of GA (µm) | 413 (467) | 459 (513) | 445 (499) |
| Eyes (%) according to central involvement at first appearance of GA | |||
| Central GA | 169 (32.7%) | 365 (33.2%) | 534 (33.4%) |
| Non-central GA | 348 (67.3%) | 734 (66.8%) | 1082 (67.0%) |
| Eyes (%) according to GA area at first appearance (disc areas) | |||
| <0.75 | 273 (52.8%) | 845 (76.9%) | 1118 (69.2%) |
| >=0.75 to <1.5 | 85 (16.4%) | 142 (12.9%) | 227 (14.0%) |
| >=1.5 to <2.0 | 34 (6.6%) | 35 (3.2%) | 69 (4.3%) |
| >=2.0 to <4 | 84 (16.2%) | 59 (5.4%) | 143 (8.8%) |
| >=4 | 41 (7.9%) | 18 (1.6%) | 59 (3.7%) |
| Eyes (%) according to GA configuration at first appearance | |||
| Small (single patch <1DA) | 184 (35.6%) | 630 (57.3%) | 814 (50.4%) |
| Multifocal | 126 (24.4%) | 271 (24.7%) | 397 (24.6%) |
| Horseshoe or ring | 44 (8.5%) | 27 (2.5%) | 71 (4.4%) |
| Solid | 132 (25.5%) | 150 (13.6%) | 282 (17.5%) |
| Indeterminate | 31 (6.0%) | 21 (1.9%) | 52 (3.2%) |
| Eyes (%) that developed neovascular AMD | 94 (18.2%) | 138 (12.6%) | 232 (14.4%) |
| Mean (SD) time to event (years) | 2.7 (1.4) | 1.8 (1.0) | 2.2 (1.2%) |
| Eyes (%) with non-central GA at first appearance that developed central GA | 178 (51.2%) | 203 (27.7%) | 381 (35.2%) |
| Mean (SD) time to event (years) | 2.4 (1.3) | 1.7 (0.8) | 2.0 (1.1) |
SD=standard deviation; DA=disc areas; GA=geographic atrophy; AMD=age-related macular degeneration; DHA=docosahexaenoic acid; EPA=eicosapentaenoic acid