Fig 5. Sex differences in the distribution of delta opioid receptor (DOR) silver-intensified gold (SIG) particles in CA3 pyramidal cell dendrites in saline-injected and oxycodone conditioned place preference rats.
A. Sal-females have a significantly lower density of DOR-SIG particles on the plasmalemma, near the plasmalemma and in total in CA3 pyramidal cell dendrites compared to saline-injected males. B. Compared to saline-injected males, the partitioning ratio of DOR-SIG particles in CA3 dendrites is significantly lower near the plasmalemma and higher in the cytoplasm of saline-injected females. C-H. Sal- and Oxy-females (SF & OF, respectively) have no changes in either the density or partitioning ratio of DOR-SIG particles in any compartment in CA3 dendrites. Compared to Sal-males (SM), Oxy-males (OM) show a decrease in the density and partitioning ratio of DOR-SIG particles near the plasmalemma (D, G) and an increase in the partitioning ratio of DOR-SIG particles in the cytoplasm of CA3 dendrites (H). ***p < 0.001, **p < 0.01, *p < 0.05; N = 3 rats per group; n = 50 dendrites per rat.