Fig. 2.

Increased expression of GFAP and vimentin in the cortex and hippocampus of hAPP-J20/GFAP-TK⁺ mice was not due to proliferation of astrocytes. A Photomicrographs of immunofluorescence staining for GFAP and Ki67 in hAPP-J20/GFAP-TK⁺ mice (scale bar, 100 μm). B Photomicrographs of immunohistochemical staining for S100β in NTG/GFAP-TK⁻, hAPP-J20/GFAP-TK⁻, NTG/GFAP-TK⁺, and hAPP-J20/GFAP-TK⁺ mice (scale bar, 100 μm). C Quantification of the number of S100β⁺ cells in the cortex of NTG/GFAP-TK⁻, hAPP-J20/GFAP-TK⁻, NTG/GFAP-TK⁺, and hAPP-J20/GFAP-TK⁺ mice (n = 20–28 per genotype; data represent mean ± SEM).