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. 2018 Sep 3;34(6):1047–1057. doi: 10.1007/s12264-018-0279-6

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.

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Fig. 5 — Optogenetic activation of either PL or IL excitatory neurons blocked the context-based analgesic effect in rats. A Training and probe paradigm. B Optogenetic activation of neurons in either PL or IL cortex affected PLLs in the hot-plate test. Note that the context-based analgesia was significantly decreased with LED-on but not with LED-off. Context A, black; Context B, grey; HT, high temperature; LT, low temperature. n = 10 in both PL and IL groups, *P < 0.05, **P < 0.01, paired t test.