TABLE 4.
Genetic association of PTX3 SNPs with invasive fungal infectiona
| SNP | Model | Genotype | No. (%) of patients with IFI | No. (%) of patients without IFI | OR (95% CI) | P value | BIC |
|---|---|---|---|---|---|---|---|
| rs2305619 | Codominant | AA | 9 (40.9) | 32 (18.2) | 1.00 | ||
| AG | 9 (40.9) | 95 (54) | 2.97 (1.04–8.4) | 0.059 | 184.5 | ||
| GG | 4 (18.2) | 49 (27.8) | 4.04 (1.1–14.96) | ||||
| Dominant | AA | 9 (40.9) | 32 (18.2) | 1.00 | |||
| AG+GG | 13 (59.1) | 144 (81.8) | 3.28 (1.24–8.69) | 0.02 | 179.5 | ||
| Recessive | AA+AG | 18 (81.8) | 127 (72.2) | 1.00 | |||
| GG | 4 (18.2) | 49 (27.8) | 2.03 (0.63–6.50) | 0.21 | 183.3 | ||
| rs3816527 | Codominant | CC | 7 (31.8) | 27 (15.3) | 1.00 | ||
| CA | 10 (45.5) | 91 (51.7) | 2.17 (0.72–6.55) | 0.17 | 186.7 | ||
| AA | 5 (22.7) | 58 (33) | 3.35 (0.9–12.16) | ||||
| Dominant | CC | 7 (31.8) | 27 (15.3) | 1.00 | |||
| CA+AA | 15 (68.2) | 149 (84.7) | 2.55 (0.9–7.16) | 0.086 | 182 | ||
| Recessive | CC+CA | 17 (77.3) | 118 (67) | 1.00 | |||
| AA | 5 (22.7) | 58 (33) | 1.97 (0.67–5.8) | 0.2 | 183.3 | ||
| rs1840680 | Codominant | AA | 10 (45.5) | 32 (18.2) | 1.00 | ||
| AG | 8 (36.4) | 92 (52.3) | 3.58 (1.26–10.2) | 0.02 | 182.4 | ||
| GG | 4 (18.2) | 52 (29.6) | 4.87 (1.33–17.8) | ||||
| Dominant | AA | 10 (45.5) | 32 (18.2) | 1.00 | |||
| AG+GG | 12 (54.5) | 144 (81.8) | 3.98 (1.52–10.4) | 0.0058 | 177.3 | ||
| Recessive | AA+AG | 18 (81.8) | 124 (70.5) | 1.00 | |||
| GG | 4 (18.2) | 52 (29.6) | 2.24 (0.7–7.2) | 0.15 | 182.8 | ||
a
Association analysis for 198 patients was adjusted for sex, age, and hematological malignancy. The SNPStats program established the dominant model as the best-fit model, which is indicated in boldface type, as are its significant associations at a P value of <0.05. IFI, invasive fungal infection.