TABLE 5.
Genotype association of PTX3 SNPs with the risk of developing invasive aspergillosisa
| SNP | Model | Genotype | No. (%) of patients with IA | No. (%) of patients without IA | OR (95% CI) | P value | BIC |
|---|---|---|---|---|---|---|---|
| rs2305619 | Codominant | AA | 6 (50) | 35 (18.8) | 1.00 | ||
| AG | 3 (25) | 101 (54.3) | 5.3 (1.21–23.26) | 0.069 | 134 | ||
| GG | 3 (25) | 50 (26.9) | 3.1 (0.68–14.14) | ||||
| Dominant | AA | 6 (50) | 35 (18.8) | 1.00 | |||
| AG+GG | 6 (50) | 151 (81.2) | 4.2 (1.22–14.57) | 0.026 | 129.1 | ||
| Recessive | AA+AG | 9 (75) | 136 (73.1) | 1.00 | |||
| GG | 3 (25) | 50 (26.9) | 1.27 (0.32–5.13) | 0.73 | 133.9 | ||
| rs3816527 | Codominant | CC | 6 (50) | 28 (15.1) | 1.00 | ||
| CA | 3 (25) | 98 (52.7) | 5.88 (1.3–26.27) | 0.044 | 133.1 | ||
| AA | 3 (25) | 60 (32.3) | 4.3 (0.94–19.78) | ||||
| Dominant | CC | 6 (50) | 28 (15.1) | 1.00 | |||
| CA+AA | 6 (50) | 158 (85) | 5.1 (1.45–17.97) | 0.013 | 127.9 | ||
| Recessive | CC+CA | 9 (75) | 126 (67.7) | 1.00 | |||
| AA | 3 (25) | 60 (32.3) | 1.63 (0.41–6.52) | 0.48 | 133.5 | ||
| rs1840680 | Codominant | AA | 6 (50) | 36 (19.4) | 1.00 | ||
| AG | 3 (25) | 97 (52.1) | 5.06 (1.15–22.2) | 0.076 | 134.2 | ||
| GG | 3 (25) | 53 (28.5) | 3.2 (0.7–14.62) | ||||
| Dominant | AA | 6 (50) | 36 (19.4) | 1.00 | |||
| AG+GG | 6 (50) | 150 (80.7) | 4.15 (1.21–14.3) | 0.027 | 129.2 | ||
| Recessive | AA+AG | 9 (75) | 133 (71.5) | 1.00 | |||
| GG | 3 (25) | 53 (28.5) | 1.36 (0.34–5.51) | 0.66 | 133.9 | ||
a
Model adjusted for sex, age, and hematological malignancy for the 198 high-risk hematology patients. The dominant model was established as the best-fit model and is indicated in boldface type, as are its significant associations at a P value of <0.05. IA, invasive aspergillosis.