TABLE 9.
Risk assessment of invasive aspergillosis for the haplotypes corresponding to rs2305619, rs3816527, and rs1840680a
| Haplotype at rs2305619-rs3816527-rs1840680 | Association risk for main haplotypes formed by PTX3 SNPs (frequency) |
|||||
|---|---|---|---|---|---|---|
| 198 patients |
140 patients with APc |
|||||
| Total | IAb | No IAb | Total | IA | No IA | |
| A-C-A | 0.424 | 0.625 | 0.411 | 0.429 | 0.687 | 0.413 |
| G-A-G | 0.523 | 0.375 | 0.532 | 0.514 | 0.312 | 0.526 |
a
Haplotype analyses were performed both on the overall population of 198 patients and on the 140 patients with AP. The assessment was adjusted for sex, age, hematological malignancy, and AP using the SNPStats program. Data represent the distributions of the two most frequent haplotypes and the association of the A-C-A haplotype with distinct infection groups. Associations at a P value of <0.05 are significant.
b
OR, 2.95 (95% CI, 1.1 to 7.91) (P value of 0.032).
c
OR, 3.12 (95% CI, 0.98 to 9.99) (P value of 0.057).