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. 2018 Oct 12;7(11):5679–5690. doi: 10.1002/cam4.1824

Figure 6.

Figure 6

High IL‐8 expression level in tumor stroma correlated with shorter overall survival in patients with pancreatic ductal adenocarcinoma (PDAC). A‐H, Representative images of IL‐8 immunohistochemical staining in PDAC tissues and normal pancreas. A, Low expression of IL‐8 both in cancer cells and tumor stroma; B, High expression of IL‐8 in cancer cells and low expression in tumor stroma; C, Low expression of IL‐8 in cancer cells and high expression in tumor stroma; D, High expression of IL‐8 both in cancer cells and tumor stroma; E, H&E staining of PDAC tissues; F, Low expression of IL‐8 in normal pancreas; G, Magnified image of (F). Several acinar cells showed strong expression of IL‐8 in cytoplasm; H, H&E staining of normal pancreas tissue. Magnification: 100× (A‐F and H) and 400× (G); Scale bars: 100 μm (A‐F and H) and 25 μm (G). I‐K, The patients were divided into low and high group according to the immunohistochemical score (IHS) of IL‐8. IHS scores of 0‐4 were regarded as low expression and 5‐12 as high expression. Kaplan‐Meier analysis of overall survival in PDAC was performed between the two groups. I, IL‐8 expression in cancer cells (high vs low); J, IL‐8 expression in tumor stroma (high vs low); K, IL‐8 expression both in cancer cells and tumor stroma (high vs low)