Table 4.
Overall top 5 symptom mean score comparison between responders and non‐responders by time
| PCR IS | 9 mo | 12 mo | 18 mo | 24 mo | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
Non‐Responder N = 8 mean |
Responder N = 28 Mean |
P |
Non‐Responder N = 21 mean |
Responder N = 20 mean |
P |
Non‐Responder N = 33 mean |
Responder P N = 15 mean |
Non‐Responder N = 35 mean |
Responder N = 18 mean |
P | ||
| Symptom | ||||||||||||
| Fatigue | 3.00 | 2.14 | 0.366 | 2.33 | 2.20 | 0.831 | 2.85 | 2.00 | 0.270 | 2.44 | 2.22 | 0.780 |
| Drowsiness | 2.88 | 1.93 | 0.331 | 2.05 | 1.50 | 0.331 | 2.27 | 1.47 | 0.242 | 1.94 | 1.83 | 0.866 |
| Sleep | 3.75 | 1.82 | 0.056 | 2.14 | 0.80 | 0.022 | 2.18 | 1.33 | 0.231 | 1.71 | 1.11 | 0.329 |
| Skin rash | 1,75 | 1.11 | 0.378 | 1.95 | 1.15 | 0.258 | 1.41 | 1.29 | 0.842 | 1.44 | 1.44 | 0.996 |
| Difficulty remembering | 2.13 | 1.78 | 0.677 | 1.52 | 1.25 | 0.687 | 1.94 | 1.20 | 0.192 | 1.88 | 1.78 | 0.871 |
| Interference with life | ||||||||||||
| WAW | 2.00 | 1.23 | 0.441 | 1.06 | 1.18 | 0.834 | 1.10 | 0.90 | 0.660 | 1.06 | 1.18 | 0.828 |
| REM | 2.10 | 1.00 | 0.195 | 1.27 | 0.93 | 0.553 | 0.78 | 0.71 | 0.858 | 0.75 | 1.12 | 0.355 |
REM, relations with others, enjoyment of life, and mood; WAW, working with others, general activity, and walking.
At 9 mo, non‐responders were defined as >0.1 PCR IS % transcripts, while responders were defined as ≤0.1 PCR IS % transcripts; at 12 mo, non‐responders were defined as >0.01 PCR IS % transcripts, while responders were defined as ≤0.01 PCR IS % transcripts; at 18 mo, non‐responders were defined as >0.0032 PCR IS % transcripts, while responders were defined as ≤0.0032 PCR IS % transcripts; at 24 mo, non‐responders were defined as >0.00001 PCR IS % transcripts, while responders were defined as ≤0.00001 PCR IS % transcripts.